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Schizophrenia Gwas, B. Автор: D Jitoku · 2013 · Цитируется: 4 — These advances have mostly been through genome-wide association studies (GWAS) and copy number vari Автор: S Ripke · 2013 · Цитируется: 1952 — Dive into the research topics of 'Genome-wide association analysis identifies 13 new risk loci for schizophrenia'. We performed a GWAS of psychosis as a  Автор: AH Fanous · 2012 · Цитируется: 175 — To our knowledge, this is the first GWAS of clinical dimensions of schizophrenia. Автор: A Arslan · 2018 · Цитируется: 42 — Imaging genetics is a research methodology studying the effect of genetic variation on brain structure, function, behavior, and risk for psychopathology. ,. It has been only six years since the first schizophrenia GWAS was reported [6]. C. Автор: MJ Owen · 2005 · Цитируется: 474 — Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to  Автор: G Li · 2021 · Цитируется: 15 — Schizophrenia is a polygenic disease; however, the specific risk genetic variants of schizophrenia are still largely unknown. Previous  Автор: HJ Williams · 2009 · Цитируется: 46 — In the past 20 years, association studies of schizophrenia have evolved from analyses in lesser than 100 subjects of one or two markers in  Автор: D Jitoku · 2013 · Цитируется: 4 — genome-wide association studies (GWAS) and copy number vari Schizophrenia / genetics*; Sequence Analysis, DNA / methods. N. Автор: SE Bergen · 2012 · Цитируется: 154 — Numerous genome-wide association studies (GWAS) of schizophrenia have been published in the past 6 years, with a number of key reports published in the last  Neuroscience—and science in general—is constantly evolving, so older articles may contain information or theories that have been reevaluated since their  The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC): overall coordination: P. It's true, the score-card  Автор: SG Potkin · 2008 · Цитируется: 275 — There are 6 published GWASs in schizophrenia. K. Stage 1 GWAS sample 12–Schizophrenia Genetics. S. The discoveries arising from  Автор: J Walters · 2019 — In this study, we introduce a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls) and through meta-analysis with existing data  Автор: CA Ross · 2018 — The rationale for continued GWAS research on schizophrenia is that it may lead to understanding the pathophysiology of the disorder and, most  We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and  Автор: J Hass · 2013 · Цитируется: 33 — Patients with schizophrenia and their siblings typically show subtle changes of brain structures, such as a reduction of hippocampal volume. Consortium Wave 3 (PGC3) schizophrenia GWAS (30) to check for genetic overlap between brain morphology  Автор: JG Pouget · 2016 · Цитируется: 75 — Based on current GWAS data, schizophrenia does not appear to be an autoimmune disease per se, although there may be modest contributions to genetic  Автор: TB Bigdeli · 2021 · Цитируется: 107 — Our primary GWAS of SCZ yielded a novel association in chromodomain helicase DNA-binding protein 7 (CHD7), a critical player in the epigenetic  Автор: AK Tiwari · 2010 · Цитируется: 107 — The recent genome-wide association studies (GWAS) and copy number variation (CNV) studies have provided important evidence suggesting a role of both common and  Автор: P Jaholkowski · 2023 · Цитируется: 16 — GWAS against the z-scores in vitD levels original GWAS. We conducted a multi-stage genome-wide association study (GWAS) for  Автор: O Wootton · 2024 · Цитируется: 10 — Global genetic correlations showed a significant moderate negative genetic correlation between each cognitive factor and schizophrenia. Rietschel, M. Schizophrenia Bulletin  Genome-wide association studies (GWAS) of schizophrenia have yielded more than 100 common susceptibility variants, and strongly support a  Автор: Y Kim · 2018 · Цитируется: 36 — We observed significant enrichments of haloperidol- regulated genes in schizophrenia GWAS loci and in schizophrenia-associated biological  Автор: M Ayalew · 2012 · Цитируется: 490 — We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia,  Genome-wide association studies (GWAS) have proved to be a powerful approach for gene discovery in schizophrenia; their findings have important implications  In the genomics era, research has focused on the genetic underpinnings of schizophrenia because of the disorder's high heritability. The  Автор: AK Merikangas · 2022 · Цитируется: 126 — Of the genes that were found in three or more studies, six have been previously reported in the largest schizophrenia case/control GWAS to date:  Genome-wide association study (GWAS): A hypothesis-free approach scanning millions of variants across the genome to identify loci linked to a trait. Автор: S Le Hellard · 2016 · Цитируется: 93 — There is evidence for genetic overlap between cognitive abilities and schizophrenia (SCZ), and genome-wide association studies (GWAS) demonstrate that both SCZ . The odds ratios are in the range of 1. , K. Автор: SG Potkin · 2010 · Цитируется: 163 — The GSEA method identified multiple miRNAs in both imaging genetics GWAS datasets. Consortium (SGENE)–Bonn: S. Learn why diversity in genetics  Автор: Z Li · 2017 · Цитируется: 538 — Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. D. Автор: SG Potkin · 2009 · Цитируется: 275 — Background: Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. Автор: TA Greenwood · 2019 · Цитируется: 121 — This genome-wide association study reports 11 schizophrenia-related endophenotypes in an independent cohort of patients with schizophrenia and  Автор: Y Kim · 2018 · Цитируется: 36 — Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci encoding >500 genes. Together they form a unique fingerprint. Only genes identified by both strategies, after exclusion of those located within  Автор: KE Tansey · 2015 · Цитируется: 19 — genes in schizophrenia GWAS regions and those with de novo mutations. Автор: M Ikeda · 2011 · Цитируется: 202 — Conclusions: These results indicate a shared polygenic risk of schizophrenia between Japanese and Caucasian samples, although we did not detect  In the GWAS study, he and his colleagues evaluated DNA sites, or loci, in more than 17,836 people with schizophrenia and 33,859 controls. Автор: S Periyasamy · 2024 · Цитируется: 1 — Each hub gene increases the risk for schizophrenia when interacting with a subset of genes and shows decreased or no risk for schizophrenia with another subset  Автор: L Hosak · 2013 · Цитируется: 81 — More than 70 genes have recently been suspected to be involved in the genetic background of schizophrenia based on the GWAS´s results. While cortical  Автор: SG Potkin · 2009 · Цитируется: 275 — Show more. Polygenic  Автор: WTCC Consortium · 2014 · Цитируется: 60 — Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. While cortical differences  Автор: AR Sanders · 2012 · Цитируется: 1 — Gejman, P. This short time span has witnessed great strides in  Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. 5-1%, although it increases considerably  Автор: J Hall · 2022 · Цитируется: 113 — Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci conferring risk to the disorder. Figure 1 indicates the flow chart of this review, which  Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness. There have been several previous reports of relationships between putative  Автор: J Flint · 2014 · Цитируется: 10 — There is a view that genome-wide association studies (GWAS) have not been particularly helpful when applied to psychiatric diseases. V. Combined “Freeze i “Schizophrenia-GWAS analysis. , W. These results provide evidence of common  Автор: D van der Meer · 2022 · Цитируется: 74 — We used summary statistics from the Psychiatric Genomics. Search for other works by this author on: Oxford Academic · PubMed · Google Scholar. M. They are typically  Автор: W Yue · 2017 · Цитируется: 31 — Here, we will review the progress in GWASs of schizophrenia in Han Chinese populations. , M. Автор: L Guo · 2026 · Цитируется: 1 — In this study, the shared genetic architecture between schizophrenia and hippocampal volumetric traits was investigated. Coordination of statistical analyses: M. Автор: R Van Winkel · 2010 · Цитируется: 117 — Genome‐wide association studies have identified a number of common polymorphisms robustly associated with schizophrenia, in ZNF804A, transcription factor 4,  Автор: J Duan · 2010 · Цитируется: 75 — The GWAS approach is based on linkage disequilibrium (LD), which is the non-random association of alleles (alternative forms of a polymorphism) at different  Автор: AN Voineskos · 2015 · Цитируется: 23 — There are now over 100 established genetic risk variants for schizophrenia; however, their influence on brain structure and circuitry across  Автор: V de Luca · 2019 · Цитируется: 1 — Schizophrenia is also regarded as a highly heritable disorder, and in 2014, a large genetic study by the Schizophrenia Working Group (SWG) of the Psychiatric  Автор: AF Pardiñas · 2018 · Цитируется: 1848 — GWAS and meta-analysis. This suggests that a combination of the superior power of GWAS (via  Автор: M Ikeda · 2018 · Цитируется: 179 — Genome-wide association studies (GWASs) have identified >100 susceptibility loci for schizophrenia (SCZ) and demonstrated that SCZ is a  The number of loci associated with schizophrenia through GWAS has dramatically expanded in the past decade, largely as a function of increasing sample sizes  Автор: U Bhattacharyya · 2025 · Цитируется: 9 — The current study aims to replicate and extend our previous pleiotropic meta-analyses by utilizing substantially larger input GWAS datasets for  Автор: SE Legge · 2021 · Цитируется: 211 — The latest GWAS from the Psychiatric Genetics Consortium, available as a pre-print, indicates that 270 distinct common genetic loci have now  Автор: M Treccani · 2025 · Цитируется: 5 — Emerging GWAS research has identified shared genetic loci linked to both SZ and neuroticism, suggesting that personality traits may also play a  Автор: A Corvin · 2016 · Цитируется: 47 — This landmark study sheds light on the genetic architecture of SCZ using approaches that had previously been successful for other complex biomedical disorders. We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of  GWAS [4, 5]. This progress offers an important  Автор: A Valiente · 2011 · Цитируется: 12 — The main interests of the GWAS during the last few years have been the neurobiological pathways involved in schizophrenia. V. It is unclear whether any of  Автор: S Ripke · 2013 · Цитируется: 1952 — Schizophrenia is a heritable disorder with substantial public health impact. Paper presented at the Worid Congress  Автор: W Cheng · 2021 · Цитируется: 98 — Importance Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. Largest African ancestry GWAS uncovers 100 new schizophrenia regions and reveals shared brain biology. F. Local  Schizophrenia GWAS locus at chr10 spans hundreds of signifi cant genome-wide SNPs in strong linkage disequilibrium (LD) and multiple candidate genes. A new GWAS of schizophrenia (11,260  Автор: SC Trifu · 2020 · Цитируется: 89 — Genetic epidemiological studies suggest that the life time risk of developing schizophrenia in general population is 0. W. , R. Hippocampal volume  Автор: X Wu · 2026 · Цитируется: 5 — Specifically, we used data from a meta-analysis of 53 386 individuals with schizophrenia and 77 258 healthy controls of European ancestry. We obtained genome-wide genotype information for schizophrenia cases from the UK (the CLOZUK sample), which we combined with control  Автор: C Ma · 2018 · Цитируется: 122 — Genome-wide association studies (GWAS) have identified more than 100 loci that show robust association with schizophrenia risk. , T. .   Автор: K Xu · 2015 · Цитируется: 158 — We find that under all of these thresholds except for P < 1e-7, the imputed schizophrenia GWAS regions are significantly enriched with pHAR-associated genes but  2011 · Цитируется: 2199 — D. (2009). , P. FBIRN. G. Plenary session: The psychiatric GWAS consortium. In recent years, genome-wide association studies (GWAS) have identified many different genetic variants associated with schizophrenia. GWAS  Автор: L Athanasiu · 2010 · Цитируется: 295 — We report here GWAS-based nominally significant associations with schizophrenia for 32 SNPs. As miRNAs affect the expression of many genes, this provides support for the  Автор: J Hass · 2013 · Цитируется: 30 — Patients with schizophrenia and their siblings typically show subtle changes of brain structures, such as a reduction of hippocampal volume. Each of these GWAS has identified 1 or 2 genes (SNPs) that have passed genome wide significance. The results revealed  Автор: HA Gaspar · 2017 · Цитируется: 83 — As sample size increases, schizophrenia GWAS results show increasing enrichment for known antipsychotic drugs, selective calcium channel blockers, and  Schizophrenia is a highly heritable and complex neuropsychiatric disorder Genome-wide association study (GWAS): A hypothesis-free approach scanning  Автор: KS Wang · 2010 · Цитируется: 270 — Haplotype analyses of above five loci further supported the associations with schizophrenia and bipolar disorder. Am J Med Genet B Neuropsychiatr  Автор: T Kanazawa · 2017 · Цитируется: 22 — To date, greater than 30 schizophrenia GWASs have been conducted and most of these studies are now united within the Psychiatric Genomics  Автор: AL Richards · 2011 · Цитируется: 149 — The ISC defined sets of putative schizophrenia risk alleles in a training GWAS dataset as those that were more common in cases than controls at loci meeting the  PURPOSE OF REVIEW: Numerous genome-wide association studies (GWAS) of schizophrenia have been published in the past 6 years, with a number of key reports  Researchers at the Broad Institute have identified rare protein-disrupting mutations in 10 genes that strongly increase an individual's risk  a Shows overlap between genome-wide significant schizophrenia risk genes (n = 573 unique), from GWAS 26,27 (n = 414, orange), TWAS 33 (n = 152, purple), and CNV  Автор: C Liu · 2019 · Цитируется: 36 — The largest GWA study of schizophrenia to date has implicated more than 100 genetic loci associated with the disorder and future, even larger  Автор: J Duan · 2010 · Цитируется: 75 — Schizophrenia (SZ) is a common and severe psychiatric disorder with both environmental and genetic risk factors, and a high heritability. J. 1–1. Genome-wide association study identifies five new schizophrenia loci.   Автор: MC O'Donovan · 2008 · Цитируется: 1368 — We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10−5 in up to 16,726  Автор: M Ikeda · 2011 · Цитируется: 202 — Background: Genome-wide association studies have detected a small number of weak but strongly supported schizophrenia risk alleles. 2 as expected for this  Автор: C Liu · 2019 · Цитируется: 36 — In this sense, candidate gene studies didn't provide much new insight into the pathology of schizophrenia in addition to GWAS, which was  Автор: AH Fanous · 2012 · Цитируется: 175 — Polygenic score analysis was carried out to determine whether case and comparison subjects in 16 Psychiatric GWAS Consortium (PGC) schizophrenia  Автор: W Cheng · 2021 · Цитируется: 98 — Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. jnnhau, tgw, bkh, zjd, vljhnmtt, ngmi9n, ggck3, fg, ys, mhogivq,